SOUTH SAN FRANCISCO, Calif.-(BUSINESS WIRE)-Exelixis, Inc. (NASDAQ:EXEL) announced today that Michael M. Morrissey, PhD, the company s president and chief executive officer, will present at the following two investor conferences during the month of September 2010: The Stifel (…)
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[Source: Business Wire]
Aryltrimethylammonium triflates and tetrafluoroborates were found to be highly reactive electrophiles in the Pd-catalyzed cross coupling with aryl Grignard reagents. The coupling reactions proceed at ambient temperature with a nearly stoichiometric quantity of Grignard reagent, (…)
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[Source: NCBI PubMed]
BI 201335 is a HCV NS3-NS4A protease inhibitor that has been shown to have potent clinical antiviral activity. It is a highly optimized non-covalent competitive inhibitor of full-length NS3-NS4A proteases of genotypes 1a and 1b with Ki values of 2.6 and 2.0 nM, respectively. Ki (…)
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[Source: NCBI PubMed]
OBJECTIVE: The aim of this meta-analysis was to compare the 24-h antihypertensive efficacy of different treatments using the smoothness index. METHODS: Data were taken from the telmisartan ambulatory blood pressure monitoring (ABPM) clinical programme. Eleven clinical trials (…)
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[Source: NCBI PubMed]
The development of aerosol medicines typically involves numerous tests on animals, due to the lack of adequate in vitro models. A new in vitro method for testing pharmaceutical aerosol formulations on cell cultures was developed, consisting of an aerosolisation unit fitting a (…)
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[Source: NCBI PubMed]
The key Pd-catalyzed cross-coupling of aryl bromides or triflates and cyclopropylmagnesium bromide in the presence of substoichiometric amounts of zinc bromide produces cyclopropyl arenes in good to excellent yields. The cross-coupling of other alkyl, cycloalkyl, and aryl (…)
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[Source: NCBI PubMed]
l-DOPA-induced dyskinesia is a debilitating, treatment-limiting adverse effect that eventually occurs in the majority of Parkinson's disease patients. This review describes the strategy of biological testing, focusing on in vivo proof-of-concept animal models. We distinguish (…)
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[Source: NCBI PubMed]
BACKGROUND: Effectiveness and safety of warfarin is associated with the time in therapeutic range (TTR) with an international normalised ratio (INR) of 2.0-3.0. In the Randomised Evaluation of Long-term Anticoagulation Therapy (RE-LY) trial, dabigatran versus warfarin reduced (…)
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[Source: NCBI PubMed]
One of the key drivers of human evolution and diversity, accounting for changes that occur between different generations of people, is explained by new research published by world-renowned scientist Professor Sir Alec Jeffreys, who discovered DNA fingerprinting at the (…)
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[Source: Medical News Today]
DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/6e510d/manufacturing_of_b) has announced the addition of the "Manufacturing of Biologics - Increasing Demand for Monoclonal Antibodies and Recombinant Proteins Drives Increases in (…)
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[Source: Business Wire]
ScienceDaily (Sep. 5, 2010) One of the key drivers of human evolution and diversity, accounting for changes that occur between different generations of people, is explained by new research published by Professor Sir Alec Jeffreys, who discovered DNA fingerprinting at the (…)
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[Source: ScienceDaily]
SOUTH SAN FRANCISCO, Calif.-(BUSINESS WIRE)-Exelixis, Inc. (Nasdaq:EXEL) announced that today it granted restricted stock units representing an aggregate of 25,200 shares of Exelixis common stock to nine new employees. The restricted stock unit awards vest as to 1/4th of the (…)
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[Source: Business Wire]
03.09.2010 - Following the successful fulfilment of various Closing conditions, the sellers of 99.3% of the shares in DeveloGen AG transferred their shares to Evotec AG. Evotec AG issues 6,750,014 new Evotec Shares from its authorized capital as part consideration for the (…)
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[Source: Bionity.com]
Oustourcing Pharma - Boehringer Ingelheim has opened its Centre of Competence (CoC) in Shanghai to optimise API and chemical intermediates sourcing in China.
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[Source: BioSpace]
Data show that treatment with a single-pill combination of telmisartan, an angiotensin receptor blocker, (ARB) and amlodipine, a calcium channel blocker (CCB) results in significant reductions in blood pressure (BP) in patients with severe hypertension.1 The data, which was (…)
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[Source: Medical News Today]
DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/2745c9/argentina_pharmace) has announced the addition of the "Argentina Pharmaceuticals and Healthcare Report Q4 2010" report to their offering. Argentina Pharmaceuticals and Healthcare (…)
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[Source: Business Wire]
FT LAUDERDALE, Fla.-(BUSINESS WIRE)-As the State of Florida grapples with a budget shortfall that is crippling its AIDS Drug Assistance Program (ADAP) and forcing the state to place more than 1,300 low-income Floridians on waiting lists to access lifesaving AIDS medications, (…)
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[Source: Business Wire]
1 Mission 1 Million - Getting to the Heart of Stroke launches announcing a worldwide effort to help prevent as many as 1 million atrial fibrillation (AF)-related strokes through increased awareness and understanding. This first-of-its kind initiative calls for the submission of (…)
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[Source: Medical News Today]
INGELHEIM, Germany-(BUSINESS WIRE)-The European Society of Cardiology (ESC) today issued revised practice guidelines for the management of atrial fibrillation (AF), including guidance on the role of a novel oral treatment, dabigatran etexilate, for the prevention of stroke (…)
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[Source: Business Wire]
DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/37adf0/eli_lilly_co_p) has announced the addition of the "Eli Lilly & Co.: PharmaVitae Profile" company profile to their offering. Introduction This analysis examines the historical and (…)
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[Source: Business Wire]
INGELHEIM, Germany-(BUSINESS WIRE)-Boehringer Ingelheim today announced that results from a pre-specified sub-group analysis of the RE-LY study (Randomized Evaluation of Long-Term Anticoagulation Therapy, Warfarin, Compared with Dabigatran) the largest atrial fibrillation (…)
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[Source: BioSpace]
STOCKHOLM-(BUSINESS WIRE)-1 Mission 1 Million Getting to the Heart of Stroke launches today announcing a worldwide effort to help prevent as many as 1 million atrial fibrillation (AF)-related strokes through increased awareness and understanding. This first-of-its kind (…)
[Read article]
[Source: Business Wire]
INGELHEIM, Germany-(BUSINESS WIRE)-Boehringer Ingelheim today announced that results from a pre-specified sub-group analysis of the RE-LY study (Randomized Evaluation of Long-Term Anticoagulation Therapy, Warfarin, Compared with Dabigatran) the largest atrial fibrillation (…)
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[Source: Business Wire]
The American Lung Association is encouraging patients with lung cancer to take charge of their diagnosis and learn about clinical trials through the Lung Cancer Clinical Trial Call to Action campaign. This service provides personalized education to quickly identify trial (…)
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[Source: Medical News Today]
DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/614240/fixed_dose_combina) has announced the addition of the "Fixed Dose Combination Products" report to their offering. Fixed dose combination (FDC) products are becoming increasingly (…)
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[Source: Business Wire]
Syntheses and structure-activity relationships (SAR) of nonsteroidal glucocorticoid receptor (GR) agonists are described. These compounds contain azaindole moieties as A-ring mimetics and display various degrees of in vitro dissociation between gene transrepression and (…)
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[Source: NCBI PubMed]
FRANKFURT, Aug 26 (Reuters) - A committee advising the U.S. Food and Drug Administration (FDA) will discuss Boehringer Ingelheim's Pradaxa pill on Sept. 20, raising the prospect of a speedy market entry for the first drug in a new class of blood thinners.
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[Source: BioSpace]
The American Medical Group Association (AMGA) and the American Medical Group Foundation (AMGF) are pleased to announce an opportunity for AMGA members to participate in a learning collaborative on care management for patients with COPD. The Best Practices Learning Collaborative (…)
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[Source: Medical News Today]
DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/e9e8b4/educating_the_mark) has announced the addition of the "Educating the Market: Creating Value Through Support of Continuing Medical Education 2010" report to their offering. Educating (…)
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[Source: Business Wire]
DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their German healthcare research database. , based on where they work, their job title, how many times they have published, where they have published, etc. The relevance can be fine (…)
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[Source: Business Wire]
DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Biomarker research database. The system uses the context in which a given person appears, using artificial intelligence techniques to find out information not otherwise visible - (…)
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[Source: Business Wire]
DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/81e154/raising_disease_st) has announced the addition of the "Raising Disease State Awareness: Best Practices in Internal Brand Messaging for New Products" report to their offering. (…)
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[Source: Business Wire]
GHENT, BELGIUM-(Marketwire - August 25, 2010) - GHENT, Belgium, 25 August 2010 - Ablynx [Euronext Brussels: ABLX] announced today its results for the six month period ending 30 June 2010, which have been prepared in accordance with the IAS 34 'Interim Financial Reporting' as (…)
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[Source: BioSpace]
Highlighted Links Coldstream Laboratories Inc. LEXINGTON, KY-(Marketwire - August 23, 2010) - Larry Kranking has been named the new President and CEO of Coldstream Laboratories Inc. (CLI), the largest sterile pharmaceutical manufacturing facility in Kentucky. Kranking, who (…)
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[Source: Marketwire]
DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Osteoarthritis research database. , based on where they work, their job title, how many times they have published, where they have published, etc. The relevance can be fine tuned (…)
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[Source: Business Wire]
LEXINGTON, KY-(Marketwire - August 23, 2010) - Highlighted Links Coldstream Laboratories Inc. Larry Kranking has been named the new President and CEO of Coldstream Laboratories Inc. (CLI), the largest sterile pharmaceutical manufacturing facility in Kentucky. Kranking, who (…)
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[Source: BioSpace]
C-Terminal carboxylic acid containing inhibitors of the NS3 protease are reported. A novel series of linear tripeptide inhibitors that are very potent and selective against the NS3 protease are described. A substantial contribution to the potency of these linear inhibitors (…)
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[Source: NCBI PubMed]
DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/bd425b/biomarkers_discov) has announced the addition of the "Biomarkers: Discovery Techniques and Applications A Global Market Overview" report to their offering. Biomarkers: Discovery (…)
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[Source: Business Wire]
DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Bioavailability / Bioequivalence database. The system uses the context in which a given person appears, using artificial intelligence techniques to find out information not (…)
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[Source: Business Wire]
DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/7f25f4/the_cardiovascular) has announced the addition of the "The Cardiovascular Market Outlook to 2015: Competitive Landscape, Global Market Analysis, Key Trends and Pipeline analysis" (…)
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[Source: Business Wire]
DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their ELISAs research database. The system uses the context in which a given person appears, using artificial intelligence techniques to find out information not otherwise visible - for (…)
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[Source: Business Wire]
DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/f48fd7/boehringer_ingelhe) has announced the addition of the "Boehringer Ingelheim GmbH: PharmaVitae Profile" company profile to their offering. This analysis examines the historical and (…)
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[Source: Business Wire]