News: Chugai

30.08.2010 | Business Wire: Research and Markets: This Essential Analysis Examines the Historical and Forecast Performance for Eli Lilly In the Prescription Pharma Sector | Business Wire

DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/37adf0/eli_lilly_co_p) has announced the addition of the "Eli Lilly & Co.: PharmaVitae Profile" company profile to their offering. Introduction This analysis examines the historical and (…)

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[Source: Business Wire]

24.08.2010 | Business Wire: Maven Semantic: The Largest Database of International Osteoarthritis Research Professionals | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Osteoarthritis research database. , based on where they work, their job title, how many times they have published, where they have published, etc. The relevance can be fine tuned (…)

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[Source: Business Wire]

24.08.2010 | BioSpace: Roche (RHHBY) Enters $1.1B Drug Deal With US's Aileron Therapeutics

BASEL, Switzerland & CAMBRIDGE, Mass.-(BUSINESS WIRE)-Aileron Therapeutics and Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that they have entered into a collaboration to discover, develop and commercialise a new class of drugs called Stapled Peptide Therapeutics. As (…)

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[Source: BioSpace]

23.08.2010 | Business Wire: Maven Semantic: The Largest Database of International Osteoporosis Research Professionals | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Osteoporosis research database. The system uses the context in which a given person appears, using artificial intelligence techniques to find out information not otherwise visible (…)

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[Source: Business Wire]

19.08.2010 | Business Wire: IMGM Laboratories GmbH and the Center for Human Genetics and Laboratory Medicine to Develop Workflows for Use of 454 Sequencing Systems in Human Genetics | Business Wire

PENZBERG, Germany-(BUSINESS WIRE)-The two German-based sister companies, IMGM Laboratories GmbH and the Center for Human Genetics and Laboratory Medicine Dr. Klein and Dr. Rost, have announced their plans to use the GS FLX System and GS Junior System from 454 Life Sciences, a (…)

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[Source: Business Wire]

15.08.2010 | NCBI PubMed: Intratumoral Localization of Aromatase and Interaction between Stromal and Parenchymal Cells in the Non-Small Cell Lung Carcinoma Microenvironment.

Estrogens produced as a result of intratumoral aromatization has been recently shown to play important roles in proliferation of human non-small cell lung carcinomas (NSCLC), but the details have remained largely unknown. Therefore, in this study, we evaluated the possible (…)

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[Source: NCBI PubMed]

17.08.2010 | Business Wire: Research and Markets: Genzyme Corporation: Pharmavitae Profile | Business Wire

DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/11e326/genzyme_corporatio) has announced the addition of the "Genzyme Corporation: PharmaVitae Profile" company profile to their offering. This analysis examines the historical and (…)

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[Source: Business Wire]

17.08.2010 | Business Wire: Real-Time Detection of Neuronal Cell Death by Impedance-Based Analysis using the xCELLigence System | Business Wire

PENZBERG, Germany-(BUSINESS WIRE)-Time course analyses of neuronal cell death and its underlying mechanisms require laborious experiments and multiple endpoint assays, often involving labelling with irritating compounds and cell disruption. A recent study (1) used the (…)

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[Source: Business Wire]

16.08.2010 | Business Wire: Maven Semantic: Database of Heart Failure Research | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Heart Failure research database. The system uses the context in which a given person appears, using artificial intelligence techniques to find out information not otherwise visible (…)

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[Source: Business Wire]

12.08.2010 | NCBI PubMed: Quantitative Analysis of the Effect of Supersaturation on in Vivo Drug Absorption.

The purpose of this study is to clarify the effects of intestinal drug supersaturation on solubility-limited nonlinear absorption. Oral absorption of a novel farnesyltransferase inhibitor (FTI-2600) from its crystalline free base and its HCl salt was determined in dogs. To (…)

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[Source: NCBI PubMed]

30.06.2010 | NCBI PubMed: A defucosylated anti-CD317 antibody exhibited enhanced antibody-dependent cellular cytotoxicity against primary myeloma cells in the presence of effectors from patients.

The humanized monoclonal antibody (mAb) against CD317 antigen (anti-HM1.24 antibody; AHM), which is highly expressed on multiple myeloma (MM), induces antibody-dependent cellular cytotoxicity (ADCC). However, the antitumor activity of AHM in the clinical setting has not been (…)

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[Source: NCBI PubMed]

12.08.2010 | Business Wire: Maven Semantic: Database of Japanese Life Sciences Research Professionals | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Japanese medical research database. The system uses the context in which a given person appears, using artificial intelligence techniques to find out information not otherwise (…)

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[Source: Business Wire]

01.01.2010 | NCBI PubMed: Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model.

Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (…)

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[Source: NCBI PubMed]

11.08.2010 | Business Wire: Maven Semantic: Database of International Leukemia Research | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Leukemia research database. , based on where they work, their job title, how many times they have published, where they have published, etc. The relevance can be fine tuned by the (…)

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[Source: Business Wire]

11.08.2010 | Business Wire: Maven Semantic: Database of International Psoriasis Research Professionals | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Psoriasis research database. , based on where they work, their job title, how many times they have published, where they have published, etc. The relevance can be fine tuned by the (…)

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[Source: Business Wire]

11.08.2010 | Business Wire: Maven Semantic: Database of International Psoriasis Research Professionals | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Psoriasis research database. , based on where they work, their job title, how many times they have published, where they have published, etc. The relevance can be fine tuned by the (…)

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[Source: Business Wire]

09.08.2010 | Medical News Today: "ACTEMRA" Humanized Anti-Human IL-6 Receptor Monoclonal Antibody Conditions For Approval (All Patients Surveillance) Lifted In Japan

Chugai Pharmaceutical Co., Ltd. [Head Office: Chuo-ku, Tokyo; President: Osamu Nagayama (hereafter, "Chugai") announced that it has received a notification from the Japanese Ministry of Health, Labour and Welfare(MHLW) that the conditions for approval (surveillance of all (…)

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[Source: Medical News Today]

09.08.2010 | Business Wire: Maven Semantic: Database of Breast Cancer Researchers | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Breast Cancer research database. The system uses the context in which a given person appears, using artificial intelligence techniques to find out information not otherwise visible (…)

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[Source: Business Wire]

09.08.2010 | Business Wire: Maven Semantic: the Largest Database of International Anemia Research Professionals | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Anemia research database. , based on where they work, their job title, how many times they have published, where they have published, etc. The relevance can be fine tuned by the (…)

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[Source: Business Wire]

09.08.2010 | Business Wire: Maven Semantic: Database of Cell Culture Research Professionals | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Cell Culture research database. , based on where they work, their job title, how many times they have published, where they have published, etc. The relevance can be fine tuned by (…)

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[Source: Business Wire]

09.08.2010 | BioSpace: Curis, Inc. (CRIS) Provides Update on Genentech (RHHBY)'s Phase II Clinical Trial of GDC-0449 in Advanced Ovarian Cancer Patients; Primary Analysis Warrant Additional Investigation, Curis Stock Falls

CAMBRIDGE, Mass.-(BUSINESS WIRE)-Curis, Inc., a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today announced that it has received preliminary results from a Phase II clinical trial of GDC-0449 from (…)

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[Source: BioSpace]

06.08.2010 | Medical News Today: "ACTEMRA" Humanized Anti-Human IL-6 Receptor Monoclonal Antibody Conditions For Approval (All Patients Surveillance) Lifted In Japan

Chugai Pharmaceutical Co., Ltd. announced today that it has received a notification from the Japanese Ministry of Health, Labour and Welfare (MHLW) that the conditions for approval (surveillance of all patients) are lifted with "rheumatoid arthritis(RA)" and (…)

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[Source: Medical News Today]

01.01.2010 | NCBI PubMed: Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats.

Interstitial lung disease has been reported in cancer patients treated with epidermal growth factor receptor tyrosine kinase inhibitors, erlotinib and gefitinib. Preclinical safety studies with erlotinib did not show any evidence for an induction of injury on intact lungs in (…)

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[Source: NCBI PubMed]

05.08.2010 | Business Wire: Progress in Cancer Research: Characterisation of a New PPAR ²/ Antagonist, GSK3787, with Roche s xCELLigence System | Business Wire

PENZBERG, Germany-(BUSINESS WIRE)-The peroxisome proliferator-activated receptors (PPAR ±, ²/ and ³) are nuclear receptors that modulate transcription of regulatory pathways involved in diseases ranging from metabolic syndrome to cancer. They therefore hold great potential (…)

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[Source: Business Wire]

03.08.2010 | Business Wire: Maven Semantic: The Largest Database of Metabolic Diseases Research Professionals | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Metabolic Diseases research database. The system uses the context in which a given person appears, using artificial intelligence techniques to find out information not otherwise (…)

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[Source: Business Wire]

03.08.2010 | Business Wire: Baylor Genome Center Standardizes on Roche NimbleGen Exome Capture Technology for Human Disease Studies | Business Wire

MADISON, Wis.-(BUSINESS WIRE)-The Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC) has standardized its target enrichment human disease research studies on Roche NimbleGen (SIX: RO, ROG; OTCQX: RHHBY) Sequence Capture Exome technology. The Baylor HGSC will (…)

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[Source: Business Wire]

29.07.2010 | NCBI PubMed: In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan.

The in vitro susceptibilities of 140 laboratory reference strains of fungi, including type strains, and 165 clinical yeast isolates from Japan towards isavuconazole compared with fluconazole (FLC), itraconazole (ITC), voriconazole and amphotericin B were measured. Broth (…)

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[Source: NCBI PubMed]

29.07.2010 | Business Wire: Researchers Solve Mystery of Uner Tan Syndrome with Targeted Next-Generation Sequencing Using Roche NimbleGen Sequence Capture and 454 Sequencing Systems | Business Wire

MADISON, Wis.-(BUSINESS WIRE)-A team of researchers from leading universities in Turkey and the United States have reported that they have identified the genetic mutation responsible for the Uner Tan Syndrome (UTS) using advanced genetic capture and sequencing technologies (…)

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[Source: Business Wire]

26.07.2010 | NCBI PubMed: Overexpression of taurine transporter in Chinese hamster ovary cells can enhance cell viability and product yield, while promoting glutamine consumption.

Transporters mediate the uptake of nutrients such as amino acids and the excretion of metabolites. The fact that transporters play crucial roles in regulating cell metabolism suggests that they might be useful targets for cell engineering to enhance the yield and/or quality of (…)

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[Source: NCBI PubMed]

27.07.2010 | Medical News Today: Roche Receives FDA Clearance For CoaguChek XS Pro System With Bar Code Reader For PT/INR Testing At The Point Of Care

Roche Diagnostics announced it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for the CoaguChek XS Pro system, a new point-of-care anticoagulation monitor with a built-in bar code reader that can automatically scan and capture operator and (…)

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[Source: Medical News Today]

27.07.2010 | Business Wire: Results from Two Multi-Site Collaborative Studies Highlight the Value of 454 Sequencing Systems for Genotyping Applications | Business Wire

PENZBERG, Germany-(BUSINESS WIRE)-454 Life Sciences, a Roche Company (SWX:RO)(SWX:ROG)(Pink Sheets: RHHBY), has announced promising new results from a multi-site collaborative research study which used the company's Genome Sequencer FLX System to perform HIV drug-resistant (…)

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[Source: Business Wire]

24.07.2010 | NCBI PubMed: IL-6 blockade preferentially inhibits Th17 differentiation in collagen-induced arthritis.

We examined the time course of cytokine production by CD4 T cells from mice with collagen-induced arthritis (CIA), and we determined the influence of interleukin-6 (IL-6) blockade on cytokine production. CD4 T cells purified from spleen were cultured with both collagen and (…)

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[Source: NCBI PubMed]

26.07.2010 | Business Wire: Research and Markets: Global Markets for Hyaluronic Acid Viscosupplementation Report Through to 2013 | Business Wire

DUBLIN-(BUSINESS WIRE)-Research and Markets (http:/www.researchandmarkets.com/research/612ac8/global_markets_for) has announced the addition of the "Global Markets for Hyaluronic Acid Viscosupplementation 2009-2013" report to their offering. Global Markets for Hyaluronic (…)

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[Source: Business Wire]

20.07.2010 | Business Wire: Roche and Exiqon Agree on Joint Marketing Approach for their RT PCR Assay Systems | Business Wire

PENZBERG, Germany-(BUSINESS WIRE)-Roche (SIX: RO, ROG; OTCQX: RHHBY) and Exiqon (NASDAQ OMX: EXQ) join marketing forces for Roche Applied Science s RealTime ready assays and Exiqon s miRCURY LNA ¢ Universal RT microRNA qPCR system. As indicated by respective links on their (…)

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[Source: Business Wire]

20.07.2010 | Business Wire: Maven Semantic: The Largest Database of International Arthritis Research Professionals | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Arthritis research database. , based on where they work, their job title, how many times they have published, where they have published, etc. The relevance can be fine tuned by the (…)

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[Source: Business Wire]

15.07.2010 | Business Wire: Identification of Valid Endogenous Control Genes for Determining Gene Expression in Human Glioma Using the Roche RealTime Ready Human Reference Gene Panel | Business Wire

PENZBERG, Germany-(BUSINESS WIRE)-Quantitative real-time reverse-transcription PCR (qPCR) is a frequently used research tool in human glioma. So far, there has been no systematic approach to analysis of suitable reference genes for reliable gene expression analysis. In a (…)

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[Source: Business Wire]

13.07.2010 | Business Wire: Macrogen, Inc. Certified as NimbleGen Array Service Provider for Korea | Business Wire

MADISON, Wis.-(BUSINESS WIRE)-Roche NimbleGen (SIX: RO, ROG; OTCQX: RHHBY) announced today that Seoul-based genomic services provider Macrogen, Inc. has officially joined the Roche NimbleGen Certified Service Provider (CSP) Program. Macrogen has been certified to process (…)

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[Source: Business Wire]

13.07.2010 | Business Wire: Maven Semantic: the Largest Database of International Toxicology Professionals | Business Wire

DUBLIN-(BUSINESS WIRE)-Maven Semantic (http:/www.mavensemantic.com) announces updates to their Toxicology database. , based on where they work, their job title, how many times they have published, where they have published, etc. The relevance can be fine tuned by the user (…)

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[Source: Business Wire]

12.07.2010 | Business Wire: U.S. and Norwegian Scientists Use 454 Sequencing Systems to Identify a Novel Virus Threatening Farmed and Wild Salmon | Business Wire

BRANFORD, Conn.-(BUSINESS WIRE)-A study published online in the journal PLoS One (1) sheds new light onto the mysterious disease which has cause widespread damage to farmed salmon populations in Norway and the United Kingdom. Heart and skeletal muscle inflammation (HSMI), an (…)

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[Source: Business Wire]

10.07.2010 | Medical News Today: FDA Clears Roche's LightCycler(R) MRSA Advanced Test For Use In The U.S.

Roche Molecular Systems, Inc. (SIX: RO, ROG; OTCQX: RHHBY) announced that the U.S. Food & Drug Administration (FDA) cleared its new LightCycler MRSA Advanced Test for the detection of methicillin-resistant Staphylococcus aureus (MRSA) for clinical use in the United States. (…)

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[Source: Medical News Today]

09.07.2010 | Medical News Today: A New Study Shows That Testing For HPV Genotypes 16 And 18 Detects Cervical Pre-Cancer Missed By Pap Test

Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that data from the ATHENA (Addressing THE Need for Advanced HPV Diagnostics) U.S. registration trial of over 47,000 women demonstrate that two human papillomavirus genotypes, HPV 16 and HPV 18, can identify those women with cervical (…)

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[Source: Medical News Today]

08.07.2010 | Business Wire: High-Resolution Melting Analysis Using the Roche LightCycler Instrument for Rapid and Reliable Methylation Detection in Archival Tissue Samples | Business Wire

PENZBERG, Germany-(BUSINESS WIRE)-Promoter hypermethylation is a frequent mechanism for the repression of gene transcription in cancer and is regarded as one of the hallmarks of cancer. Analysis of DNA methylation is a promising tool for early cancer detection, risk (…)

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[Source: Business Wire]