This is the RSS news feed of one of our free news channels on LSIS - The Life Science Infromation Service. Please visit us to find a current view of this one and many more channels via our alerting push services: http://www.lsis.com/channels/?query=8 http://www.lsis.com/goto/r8/rss 2012-05-21T11:10:09+01:00 text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 Cytotoxic fusion proteins for tumor therapy are composed of an antibody-based targeting moiety and an effector molecule. Effectors may possess enzymatic activity confering cytoxicity after internalization or be an antibody-targeted death-receptor ligand that induces apoptosis after interaction with a death receptor. In this review, we focus on cytotoxic fusion proteins which, in most cases, are composed of fully human targeting and effector moieties. Regarding the first category, as outlined (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 Fluorescent agents with specificity to cellular and subcellular moieties present promise for enhancing diagnostics and theranostics, yet challenges associated with regulatory approvals of experimental agents stifle the clinical translation. As a result, targeted fluorescent agents have remained predominantly as preclinical imaging tools. We discuss the potential of using optically labeled drugs to accelerate the clinical acceptance of optical and optoacoustic agents, in analogy to nuclear (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8177751 |-| Title: Conveying device in or for an apparatus for administering a drug |-| Inventors: Feldmann; Peter (Oberburg, CH), Haenggi; Roger (Nunningen, CH), Niklaus; Hanspeter (Riken, CH) |-| Assignee: Roche Diagnostics International AG (Steinhausen, CH) |-| A conveying device in or for an apparatus for administering a product, including a base, a first conveying member which can be moved relative to the base and includes a first thread, a second conveying member (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8180423 |-| Title: Sensor with increased biocompatibility |-| Inventors: Mang; Andre (Grenzach-Whylen, DE), Buck, Jr.; Harvey B. (Indianapolis, IN), Garrison; Michael D. (Sparta, NJ), Jernigan; Walter (Indianapolis, IN) |-| Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN) |-| Sensors and methods for producing them are disclosed. A cavity is created and filled with a reagent that includes a conductive matrix, enzyme, catalyst, and binding agent, in a (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 Screening for diabetic nephropathy is usually done by albuminuria/24h and the use of creatinine clearance. The objective of this study was to evaluate the renal function in Type 2 diabetes by using different formulas of creatinine clearance and to assess the contribution of cystatin C; 83 adults with type 2 diabetes (23 men and 60 women) and 83 adult controls (40 men and 43 women) were studied. Biochemical parameters were determinated on Coba 6000? (Roche diagnostics). Diabetics showed a (…) text/html http://www.clinicaltrials.gov ClinicalTrials.gov http://www.lsis.com/channels/?query=8 The aims of the study are to prove correlation between laboratory and patient self-testing (PST) measurements, estimation of INR variability within a target therapeutic zone and frequency of hemorrhagic and/or thromboembolic events after mechanical heart valve replacement. |-| Patient INR Self-Testing Program Improves the Quality of Oral Anticoagulant Therapy After Mechanical Heart Valve Replacement |-| University Hospital, Clermont-Ferrand, St. Jude Medical, Roche Diagnostics Mannheim, (…) text/html http://www.clinicaltrials.gov ClinicalTrials.gov http://www.lsis.com/channels/?query=8 The European CRT survey represents a joint initiative between two ESC associations; the Heart Failure Association and the European Heart Rhythm Association. The survey will be performed in collaboration with The Institute für Herzinfarktforschung in Ludwigshafen which will handle the data collection and data analysis. |-| European Cardiac Resynchronisation Therapy Survey |-| Helse Stavanger HF, Boston Scientific Corporation, Medtronic, St. Jude Medical, Biotronik SE & Co. KG, Sorin Group, (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8172866 |-| Title: Medical aid |-| Inventors: List; Hans (Hesseneck-Kailbach, DE) |-| Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN) |-| The invention relates to a medical aid which comprises a lancet. The lancet is at least partially enclosed by a packaging that comprises a flexible film section. The lancet is arranged displaceably between upper and lower protective sections of the packaging. The flexible film section is detachably connected, along at (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8172811 |-| Title: Drug delivery pump drive using a shaped memory alloy wire |-| Inventors: Roe; Steven N. (San Mateo, CA) |-| Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN) |-| A pump drive and a method thereof to dispense a liquid drug from a container having a plunger piston are disclosed. The pump drive provides a unidirectional clutch provided about a rotational axis which supports centrally a wheel. The clutch has an inner race operably connected to (…) text/html http://www.clinicaltrials.gov ClinicalTrials.gov http://www.lsis.com/channels/?query=8 The purpose of this study is to determine whether self-management of oral anticoagulation therapy with warfarin has an effect on patient's quality of life following a specific training program led by pharmacists. |-| Evaluation of Self-monitoring of Oral antiCoagulant therApy by the PatiEnts |-| Montreal Heart Institute, Roche Diagnostic Ltd. |-| Canada, Quebec Montreal Heart Institute Recruiting Montreal, Quebec, Canada, H1T 1C8 Contact: Simon Tremblay, B.Pharm, MSc 514-376-3330 ext 3510 (…) text/html http://www.clinicaltrials.gov ClinicalTrials.gov http://www.lsis.com/channels/?query=8 Establishing new biochemical markers in the differential diagnostics and risk stratification in heterogeneous patient collectives is becoming more and more important. The markers should be objective, reliable, reproducible, quick and cost effective as well as specific and sensitive. Concerning the differential diagnostics of dyspnea, NT-pro-BNP plays the most important role for the evaluation of a cardiac origin. However, a corresponding biochemical marker for pulmonary stress is lacking. The (…) text/html http://www.clinicaltrials.gov ClinicalTrials.gov http://www.lsis.com/channels/?query=8 The effect of change in diabetes treatment from multiple daily insulin injection therapy to continuous subcutaneous insulin infusion on psychosocial outcome measures (quality of life, diabetes burden, parents stress level, fear, family conflicts) in families with children and adolescents with diabetes mellitus type 1 will be analysed. Additionally the effect on metabolic parameters (HbA1c, severe Hypoglycemia, Ketoacidosis) will be analysed. |-| Psychosocial Issues in Insulin Pump Therapy in (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 PURPOSETo determine the maximum-tolerated dose (MTD) and assess safety, pharmacokinetics, pharmacodynamics, and evidence of antitumor activity of RO4929097, a gamma secretase inhibitor of Notch signaling in patients with advanced solid malignancies. PATIENTS AND METHODSPatients received escalating doses of RO4929097 orally on two schedules: (A) 3 consecutive days per week for 2 weeks every 3 weeks; (B) 7 consecutive days every 3 weeks. To assess reversible CYP3A4 autoinduction, the expanded (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 PURPOSE: In this study, we correlate results of bioluminescence measurements with established readouts for assessing therapeutic efficacy of antibodies in orthotopic cancer xenografts. PROCEDURES: An orthotopic tumor model of pancreatic cancer (AsPC-1-luc) and experimental lung metastasis (A549-luc) were established. Whole-body bioluminescence imaging (BLI) was performed to observe tumor progression under therapy with antibodies targeting different receptor kinases (primary readout). For (…) text/html http://www.biospace.com BioSpace http://www.lsis.com/channels/?query=8 Recall Class: Class I Date Recall Initiated: March 12, 2012 Product: Elecsys Troponin I and Elecsys Troponin I STAT Immunoassays Lot numbers: 163176, 163177 Use: Elecsys Troponin I and Elecsys Troponin I STAT Immunoassays are used to determine heart damage as an aid in the diagnosis of a heart attack. Distribution Dates: June 29, 2011 through January 13, 2012 Recalling Firm: Roche Diagnostics Operations, Inc. 9115 Hague Road Indianapolis, Indiana 46256-1025 Reason for Recall: With certain (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 We evaluated quantitative hepatitis B surface antigen (qHBsAg) assays and a hepatitis B virus (HBV) core-related antigen (HBcrAg) assay. A total of 529 serum samples from patients with hepatitis B were tested. HBsAg levels were determined by using the Elecsys (Roche Diagnostics, Indianapolis, IN) and Architect (Abbott Laboratories, Abbott Park, IL) qHBsAg assays. HBcrAg was measured by using Lumipulse HBcrAg assay (Fujirebio, Tokyo, Japan). Serum aminotransferases and HBV DNA were respectively (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 MLO Med Lab Obs. |-| Lee JA, Payette M, Osiecki J. |-| Medical and Scientific Affairs, Roche Diagnostics, Indianapolis, USA. text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 We carried out a prospective study comparing the performance of human papillomavirus (HPV) E6/E7 mRNA (PreTect HPV-Proofer NorChip, Klokkarstua, Norway) and DNA (AMPLICOR HPV Test, Roche Diagnostics, Basel, Switzerland) triage testing of women 6-12 months after atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) cytology in organised screening to predict high-grade cervical intraepithelial neoplasia grade 2 or worse (CIN2+) (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 This special issue of New Biotechnology is focused on molecular diagnostics and personalised medicine and appears at an epochal moment in the development of the field. The practice of medicine is taking a significant and irrevocable turn towards personalisation, due to the great progress in areas such as genomics, pharmacogenomics and molecular diagnosis. It becomes increasingly apparent that to deliver the promise of personalised treatments, more and more novel medicines discovered today will (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8157750 |-| Title: Integrated analytical test element |-| Inventors: Raney; Charles C. (Camdenton, MO), Roe; Steven N. (San Mateo, CA) |-| Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN) |-| A lancet integrated test element (LIT) includes an incision forming member that has a cutting end configured to form an incision in tissue. A test element is attached to the incision forming member to test fluid from the incision. The test element has a sampling end (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8157746 |-| Title: Device for cutting out tissue specimens |-| Inventors: Eberle; Walter (Bernried, DE), Hloch; Peter (Kochel, DE), Hundt; Christoph (Munich, DE), Rainer; Alois (Munich, DE) |-| Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN) |-| The present invention relates to a device for separating a tissue part from brain material, the device comprising a circular blade which continues as the wall of a cylindrical or substantially cylindrical hollow (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8152741 |-| Title: Lancet wheel |-| Inventors: Hoenes; Joachim (Zwingenberg, DE), List; Hans (Hesseneck-Kailbach, DE), Zimmer; Volker (Laumersheim, DE), Hoerauf; Christian (Oftersheim, DE), Kraemer; Uwe (Ilvesheim, DE) |-| Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN) |-| The invention is related to a lancet wheel (1) having a plurality of lancets (2) in a ring-shaped arrangement, the lancets (2) comprising a lancet body (4) that ends in a lancet tip (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8152740 |-| Title: Blood withdrawal system |-| Inventors: Thoes; Bruno Robert (Quierschied, DE), Schabbach; Michael (Weinheim, DE), Kintzig; Hans (Tiefenthal, DE), Ruschke; Peter (Budenhiem, DE), Kuhr; Hans (Mannheim, DE) |-| Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN) |-| The present invention generally relates to a blood withdrawal system for withdrawing blood for diagnostic purposes. The blood withdrawal system comprises housing with a lancet, which (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 BACKGROUND: Vitamin D testing is becoming increasingly important with recent research demonstrating a correlation between vitamin D insufficiency and metabolic diseases, immunodeficiencies and other diseases. However, existing 25-hydroxyvitamin D (25OHD) assays lack comparability to the candidate reference method, causing difficulties in diagnosis and monitoring of vitamin D deficiency. METHODS: We looked at the accuracy of 3 automated assays (Roche Diagnostics Elecsys Total 25OHD assay, (…) text/html http://www.biospace.com BioSpace http://www.lsis.com/channels/?query=8 Heidelberg, Germany, April 2, 2012 / B3C newswire / - The BioRN Annual Conference will take place in Heidelberg on May 15, 2012. With the topic "Mobilizing Seed and Venture Capital for Health Innovation" the conference in the Biotech Cluster Rhein-Neckar (BioRN) wishes to highlight global trends in the funding of young biotech enterprises. With the presentation of successful international examples it is intended to stimulate political and cultural changes towards a more entrepreneurial (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 A new hepatitis C virus (HCV) core antigen (HCV Ag) assay was thought to have a good correlation with HCV RNA. The aim was to elucidate the usefulness of this HCV Ag assay in community screening. In an HCV-endemic township, 405 residents aged 58 years or older, responded to a follow-up community screening. All subjects were tested for anti-HCV (HCV 3.0, AxSYM, Abbott) and HCV Ag (HCV Ag, Architect, Abbott). For subjects with anti-HCV signal to cut-off ratio (S/CO) 10 and/or HCV Ag 3 fmol/L, (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 BACKGROUND: Measurement of high-sensitive cardiac troponin (hs-cTn) has facilitated the early diagnostic assessment of chest pain patients. However, the information obtained from hs-cTnT levels might be improved when combined with results of other biomarkers of myocardial injury. METHODS: We measured admission levels of hs-cTnT (Roche Diagnostics), heart-type fatty-acid binding protein (H-FABP; Randox Laboratories) and copeptin using a novel ultra-sensitive (us) assay (Thermo Fisher (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 A rapid and sensitive method for the screening and quantification of 35 benzodiazepines in human urine by gas chromatography/time-of-flight mass spectrometry was developed and validated. Target analytes were isolated from 1 ml urine by solid-phase extraction using Oasis MCX extraction columns (extraction recovery between 35 and 99 %). With a supported liquid-liquid extraction method, a new modification of conventional liquid-liquid-extraction, a less time intensive alternative for (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 Abstract Objectives: Blood glucose meters for patient self-measurement need to comply with the accuracy standards of the ISO 15197 guideline. We investigated the accuracy of the two new blood glucose meters BG*Star and iBG*Star (Sanofi-Aventis) in comparison to four other competitive devices (Accu-Chek Aviva, Roche Diagnostics; FreeStyle Freedom Lite, Abbott Medisense; Contour, Bayer; OneTouch Ultra 2, Lifescan) at different blood glucose ranges in a clinical setting with healthy subjects and (…) text/html http://www.biospace.com BioSpace http://www.lsis.com/channels/?query=8 22 March 2012 - TAP Biosystems, a leading supplier of innovative cell culture systems and consumables for life science applications, today announces that Dr Mike Evans will become Non-Executive Chairman following Matthew Bullock s retirement after 13 years on 31st March 2012, and that Dr Manfred Baier will join the Board as a non-executive Director. Dr Mike Evans has over 20 years experience in directing the commercial and operating strategy of major life science companies, including GE (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 Measurement of estrone (E1) and estradiol (E2) values text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 BACKGROUND: The limitations of serum testosterone (T) and estradiol (E2) measurements using non-extraction platform immunoassays (IA) are widely recognized. Switching to more specific mass spectrometry (MS) -based methods has been advocated but directly comparative data on the two methods are scarce.METHODS: We compared serum T and E2 measurements in a large sample of middle-aged/elderly men using a common platform IA and a gas chromatography (GC)-MS method, in order to assess their (…) text/html http://www.biospace.com BioSpace http://www.lsis.com/channels/?query=8 MILPITAS, CA-(Marketwire - March 13, 2012) - AmbiCom Holdings, Inc. (OTCQB: ABHI) (PINKSHEETS: ABHI), a leading designer and developer of wireless products for the medical industry, today announced that for the second year in a row it has received the highest quality assessment for its shipments to Roche Diagnostics. Annually Roche makes a quality ranking based on correct and incorrect deliveries made to them. At the end of each year, the customer determines a quality code - those who rank (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 Background: Many patients do not intensify their insulin regimens. It is believed that lack of adherence may be largely due to fear of hypoglycemia. We hypothesized that utilization of an automated bolus calculator (bolus advisor) might reduce fear of hypoglycemia and encourage patients to achieve improved glycemic control. Method: We surveyed 1,412 type 1 diabetes mellitus (T1DM) patients treated with multiple daily insulin injection therapy at 270 hospitals in the United Kingdom and Republic (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 For every drug development program it needs to be discussed whether discrimination between free and total drug concentrations is required to accurately describe its pharmacokinetic behavior. This perspective describes the application of mathematical simulation approaches to guide this initial decision based on available knowledge about target biology, binding kinetics and expected drug concentrations. We provide generic calculations that can be used to estimate the necessity of free drug (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 In the bitch, the oviduct is the site of oocyte maturation (Day 1 to 3 after ovulation), sperm transport/capacitation, fertilization (Day 3 to 4) and embryo development to the morula/blastocyst stage (Day 4 to 8). Unlike other mammals, these events occur in the presence of high ( 6ngmL(-1) and increasing plasma levels of progesterone (P4), but little is known about the regulation of oviductal functions by P4 in the bitch. The objective of this work was to study the mRNA expression of nuclear (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 The study presents the results obtained by LightSNiP method with the use of 2 SNPs located on Y chromosome. The purpose of this study was examination of the mixture of the genetic material in the form of male and female blood in different dilutions. The size of available STR-PCR markers is between 100 and 500 bp, which can limit the possibility of DNA mixture analysis, where the amount of male DNA is relatively low or the genetic material is markedly degraded. Selection of appropriate SNPs (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 Expression of CHO mRNA was measured with special microarrays from the Consortium for Chinese Hamster Ovary (CHO) Cell Genomics led by Prof. Wei-Shou Hu of the University of Minnesota and Prof. Miranda Yap of the Bioprocess Technology Institute of A*STAR, Singapore(http:/hugroup.cems.umn.edu/CHO/cho_index.html). Cultivation experiments were performed in small scale 2L stirred tank bioreactors. During fermentation a temperature shift of -3°C was performed. This was accompanied by a reduction (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 BMC Proc. |-| Diekmann S, Dürr C, Herrmann A, Lindner I, Jozic D. |-| Roche Diagnostics GmbH, Pharma Biotech Penzberg, 82377 Penzberg, Germany. Sonja.Diekmann@roche.com. text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 BMC Proc. |-| Puskeiler R, Kreuzmann J, Schuster C, Didzus K, Bartsch N, Hakemeyer C, Schmidt H, Jacobs M, Wolf S. |-| Roche Diagnostics GmbH, Pharma Biotech, Development Fermentation, Penzberg, Germany, 82377. robert.puskeiler@roche.com. text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 A fast and sensitive reference method for quantification of ?(9) -tetrahydrocannabinol (THC) and its main metabolite 11-nor-9-carboxy-?(9) -tetrahydrocannabinol (THCCOOH) in oral fluid is described in this study. Samples were collected using an oral specimen collection device, followed by solid-phase extraction and liquid chromatography-tandem mass spectrometry analysis. Chromatographic separation of the analytes was achieved by gradient elution on a reversed-phase column with subsequent (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 BMC Proc. |-| Markert S, Joeris K. |-| Roche Diagnostics GmbH, Pharma Biotech Production and Development, Penzberg, Germany. Sven.Markert@roche.com. text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 BMC Proc. |-| Druhmann D, Reinhard S, Schwarz F, Schaaf C, Greisl K, Nötzel T. |-| Roche Diagnostics GmbH, Pharma Biotech Penzberg. text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 The aim was to examine whether high sensitive troponin T (Hs-TnT) is better than conventional troponins to risk stratify chest pain patients, in particular when applying early serial measurements or combining with natriuretic peptides. Samples were obtained on admission and after 2h in 231 chest pain patients who were followed for a median time of 22months. Troponin levels were determined by Hs-TnT, conventional TnT (Roche Diagnostics) and troponin I (Beckman Coulter) assays. N-terminal pro (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8123701 |-| Title: Methods and apparatus for sampling and analyzing body fluid |-| Inventors: Douglas; Joel S. (Groton, CT), Roe; Jeffrey N. (San Ramon, CA), Radwanski; Ryszard (Lublin, PL), Duchon; Brent G. (Cypress, CA) |-| Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN) |-| A sampling device for sampling body fluid includes a lancet for making an incision, a capillary tube for drawing-up body fluid from the incision, and a test strip affixed to an upper (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8123717 |-| Title: Therapy delivery system having an open architecture and a method thereof |-| Inventors: Weinert; Stefan (Pendleton, IN), Thukral; Ajay (Indianapolis, IN), Galley; Paul (Cumberland, IN), Chittajallu; Siva (Indianapolis, IN), Bousamra; Steven (Carmel, IN), Long; James (Fishers, IN) |-| Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN) |-| A therapy delivery system having an open architecture and method of providing thereof are disclosed. The (…) text/html http://www.uspto.gov/ USPTO http://www.lsis.com/channels/?query=8 United States Patent: 8124338 |-| Title: Use of TDE for isolation of nucleic acids |-| Inventors: Donner; Horst (Penzberg, DE), Bergmann; Frank (Iffeldorf, DE), Lassonczyk; Nina (Penzberg, DE), Watzele; Manfred (Weilheim, DE), Schmid; Marcus (Wessobrunn, DE) |-| Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN) |-| The invention provides the use of tetraethylene glycol dimethyl ether for adsorbing nucleic acids to solid phases such as those with silica surfaces. To this end, the (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 The performance of three line blot assays (LBA) - Linear Array HPV genotyping assay (LA; Roche Diagnostics), INNO-LiPA HPV Genotyping Extra (LiPA; Innogenetics) and the Reverse Hybridization assay (RH; Qiagen) was evaluated using quantitated whole genomic HPV plasmids (types 6, 11, 16, 18, 31, 33, 35, 39, 51, 52, 56, 58, 59, 68b) as well as epidemiologic samples. In a plasmid titration series LiPA and RH did not detect 50 international units (IU) of HPV 18 in the presence of 5 à 10(4) or more (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 INTRODUCTION: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by chronic joint inflammation and extra-articular manifestations, eventually leading to permanent disability without early therapeutic interventions. METHODS: The analytical and clinical performance of an electrochemiluminescent immunoassay (ECLIA) (Roche Diagnostics, Indianapolis, IN) were determined for cyclic citrullinated peptide antibodies (anti-CCP) in the diagnostic assessment of rheumatoid (…) text/html http://www.ncbi.nlm.nih.gov NCBI PubMed http://www.lsis.com/channels/?query=8 MLO Med Lab Obs. |-| McCune J. |-| Roche Diagnostics, Indianapolis, USA.